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| First Round Draft Pick History |
| 1 | 15 | 15 | 2007 | Annual Draft | P | Daisuke | Matsuzaka | MLB |
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| 1 | 13 | 13 | 2006 | Annual Draft | C | Russell | Martin | MLB |
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| 1 | 9 | 9 | 2005 | Annual Draft | P | Huston | Street | MLB |
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| 1 | 12 | 12 | 2005 | Annual Draft | 3B | Edwin | Encarnacion | MLB |
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| 1 | 16 | 16 | 2005 | Annual Draft | P | Francisco | Liriano | MLB |
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| 1 | 2 | 2 | 2004 | Annual Draft | OF | Matt | Holliday | MLB |
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| 1 | 15 | 15 | 2004 | Annual Draft | P | Erik | Bedard | MLB |
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| Complete Draft History |
| 1 | 15 | 15 | 2007 | Annual Draft | P | Daisuke | Matsuzaka | MLB |
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| 2 | 11 | 27 | 2007 | Annual Draft | P | Dustin | McGowan | MLB |
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| 3 | 12 | 44 | 2007 | Annual Draft | P | Manny | Delcarmen | MLB |
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| 3 | 15 | 47 | 2007 | Annual Draft | P | Jensen | Lewis | MLB |
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| 4 | 1 | 49 | 2007 | Annual Draft | P | Kyle | Kendrick | MLB |
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| 4 | 8 | 56 | 2007 | Annual Draft | P | Joe | Smith | MLB |
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| 1 | 13 | 13 | 2006 | Annual Draft | C | Russell | Martin | MLB |
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| 2 | 10 | 26 | 2006 | Annual Draft | 2B | Ryan | Theriot | MLB |
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| 3 | 13 | 45 | 2006 | Annual Draft | 2B | Esteban | German | MLB |
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| 5 | 13 | 77 | 2006 | Annual Draft | P | Rick | Bauer | MLB |
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| 6 | 10 | 90 | 2006 | Annual Draft | 3B+ | Nick | Punto | MLB |
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| 7 | 13 | 109 | 2006 | Annual Draft | OF | Endy | Chavez | MLB |
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| 1 | 9 | 9 | 2005 | Annual Draft | P | Huston | Street | MLB |
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| 1 | 12 | 12 | 2005 | Annual Draft | 3B | Edwin | Encarnacion | MLB |
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| 1 | 16 | 16 | 2005 | Annual Draft | P | Francisco | Liriano | MLB |
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| 2 | 7 | 23 | 2005 | Annual Draft | P | Clay | Hensley | MLB |
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| 2 | 10 | 26 | 2005 | Annual Draft | P | Chris | Ray | MLB |
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| 3 | 9 | 41 | 2005 | Annual Draft | 3B | Aaron | Hill | MLB |
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| 4 | 7 | 55 | 2005 | Annual Draft | 2B | Jose | Castillo | MLB |
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| 5 | 9 | 73 | 2005 | Annual Draft | P | Jay | Witasick | MLB |
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| 1 | 2 | 2 | 2004 | Annual Draft | OF | Matt | Holliday | MLB |
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| 1 | 15 | 15 | 2004 | Annual Draft | P | Erik | Bedard | MLB |
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| 2 | 11 | 27 | 2004 | Annual Draft | C | Johnny | Estrada | MLB |
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| 3 | 15 | 47 | 2004 | Annual Draft | SS+ | Deivi | Cruz | MLB |
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| 4 | 11 | 59 | 2004 | Annual Draft | P | Ryan | Drese | MLB |
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| 5 | 15 | 79 | 2004 | Annual Draft | OF | Eric | Byrnes | MLB |
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| 6 | 11 | 91 | 2004 | Annual Draft | P | Tomo | Ohka | MLB |
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| 7 | 15 | 111 | 2004 | Annual Draft | P | Yhency | Brazoban | MLB |
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| 8 | 11 | 123 | 2004 | Annual Draft | P | Ricky | Bottalico | MLB |
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| 9 | 15 | 143 | 2004 | Annual Draft | 2B | Jeff | Keppinger | MLB |
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| 10 | 11 | 155 | 2004 | Annual Draft | OF+ | John | Mabry | MLB |
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| 11 | 15 | 175 | 2004 | Annual Draft | OF | Wily Mo | Pena | MLB |
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| 12 | 11 | 187 | 2004 | Annual Draft | 1B+ | Olmedo | Saenz | MLB |
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| 13 | 15 | 207 | 2004 | Annual Draft | OF+ | David | Newhan | MLB |
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| 14 | 11 | 219 | 2004 | Annual Draft | P | Fernando | Cabrera | MLB |
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