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| First Round Draft Pick History |
| 1 | 7 | 7 | 2008 | Annual Draft | 2B | Alexei | Ramirez | MLB |
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| 1 | 16 | 16 | 2007 | Annual Draft | P | Joakim | Soria | MLB |
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| 1 | 5 | 5 | 2004 | Annual Draft | C | Yadier | Molina | MLB |
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| Complete Draft History |
| 1 | 7 | 7 | 2008 | Annual Draft | 2B | Alexei | Ramirez | MLB |
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| 2 | 3 | 19 | 2008 | Annual Draft | P | Nick | Blackburn | MLB |
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| 3 | 7 | 39 | 2008 | Annual Draft | P | Andy | Sonnanstine | MLB |
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| 4 | 15 | 63 | 2008 | Annual Draft | P | Steven | Shell | MLB |
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| 5 | 7 | 71 | 2008 | Annual Draft | P | Jose | Contreras | MLB |
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| 6 | 15 | 95 | 2008 | Annual Draft | P | Jeff | Samardzija | MLB |
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| 7 | 7 | 103 | 2008 | Annual Draft | P | Franklyn | German | MLB |
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| 8 | 15 | 127 | 2008 | Annual Draft | P | Mike | MacDougal | MLB |
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| 9 | 7 | 135 | 2008 | Annual Draft | C | Chris | Coste | MLB |
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| 1 | 16 | 16 | 2007 | Annual Draft | P | Joakim | Soria | MLB |
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| 2 | 12 | 28 | 2007 | Annual Draft | SS | Brendan | Harris | MLB |
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| 3 | 16 | 48 | 2007 | Annual Draft | OF | Ryan | Spilborghs | MLB |
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| 4 | 12 | 60 | 2007 | Annual Draft | C | Kurt | Suzuki | MLB |
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| 5 | 16 | 80 | 2007 | Annual Draft | OF | Garret | Anderson | MLB |
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| 6 | 12 | 92 | 2007 | Annual Draft | P | Josh | Fogg | MLB |
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| 7 | 16 | 112 | 2007 | Annual Draft | P | Matt | Chico | MLB |
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| 4 | 11 | 59 | 2006 | Annual Draft | P | Micah | Bowie | MLB |
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| 5 | 14 | 78 | 2006 | Annual Draft | P | Chad | Gaudin | MLB |
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| 6 | 11 | 91 | 2006 | Annual Draft | OF | Marlon | Byrd | MLB |
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| 7 | 14 | 110 | 2006 | Annual Draft | P | Noah | Lowry | MLB |
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| 8 | 11 | 123 | 2006 | Annual Draft | OF | Nate | McLouth | MLB |
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| 5 | 10 | 74 | 2005 | Annual Draft | P | Josh | Hancock | MLB |
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| 5 | 14 | 78 | 2005 | Annual Draft | P | Jack | Taschner | MLB |
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| 6 | 10 | 90 | 2005 | Annual Draft | P | David | Bush | MLB |
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| 6 | 13 | 93 | 2005 | Annual Draft | P | R.A. | Dickey | MLB |
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| 1 | 5 | 5 | 2004 | Annual Draft | C | Yadier | Molina | MLB |
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| 2 | 2 | 18 | 2004 | Annual Draft | SS | Khalil | Greene | MLB |
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| 3 | 5 | 37 | 2004 | Annual Draft | SS | Freddy | Sanchez | MLB |
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| 3 | 16 | 48 | 2004 | Annual Draft | 2B | Michael | Cuddyer | MLB |
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| 5 | 5 | 69 | 2004 | Annual Draft | P | Nate | Robertson | MLB |
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| 6 | 2 | 82 | 2004 | Annual Draft | P | Chris | Young | MLB |
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| 7 | 5 | 101 | 2004 | Annual Draft | OF | Gary | Matthews | MLB |
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| 8 | 2 | 114 | 2004 | Annual Draft | P | Todd | Jones | MLB |
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| 9 | 5 | 133 | 2004 | Annual Draft | P | Scott | Eyre | MLB |
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| 10 | 2 | 146 | 2004 | Annual Draft | P | Ryan | Dempster | MLB |
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| 11 | 5 | 165 | 2004 | Annual Draft | P | Jay | Witasick | MLB |
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| 12 | 2 | 178 | 2004 | Annual Draft | OF | David | DeJesus | MLB |
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| 13 | 5 | 197 | 2004 | Annual Draft | P | Kevin | Gryboski | MLB |
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